Pemphigus and Pemphigoid are rare autoimmune disease in which autoantibodies attack proteins of the skin and mucous membranes causing blister.
The blisters can affect all mucous membranes, including those of the mouth and pharynx, and the skin of the whole body causing painful lesions which create a great fluid loss, electrolytes and heat. In case of extensive injuries, dehydration and electrolyte loss may also be fatal. Pemphigus Vulgaris despite a correct therapy sees significant mortality.
Often mucosal lesions of the oral cavity and oropharynx may precede the skin lesions even several months, It is therefore important that the Otolaryngologist suspects this disease to correctly identify the problem and you can set the therapy that is based on immunosuppressive drugs.
